Follistatin 344Follistatin 344
Myostatin-binding glycoprotein that promotes muscle hypertrophy by blocking negative growth regulation.
Available Forms
Key Benefits
Overview
Follistatin 344 is a recombinant form of the naturally occurring glycoprotein follistatin, specifically the FS-344 isoform, which functions as a potent antagonist of myostatin and other members of the TGF-beta superfamily. Myostatin is a negative regulator of skeletal muscle mass, and its inhibition by follistatin has been shown to produce dramatic increases in muscle fiber size and number in preclinical models. Research in murine studies demonstrated that follistatin-mediated myostatin blockade can produce muscle hypertrophy exceeding 60% above baseline, significantly surpassing the effects of resistance training alone. Beyond its myogenic properties, follistatin has been investigated for its role in reproductive biology, inflammation modulation, and tissue regeneration. The FS-344 variant's extended circulating half-life and broad TGF-beta neutralization profile make it a compelling subject in muscle wasting disease research, sarcopenia intervention, and regenerative medicine applications.
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