AOD-9604AOD-9604
Lipolytic peptide fragment of human growth hormone targeting fat metabolism without blood sugar impact.
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Overview
AOD-9604 is a modified synthetic peptide comprising the C-terminal fragment of human growth hormone (hGH) residues 177-191, specifically engineered to replicate the lipolytic (fat-burning) properties of the full hormone without its proliferative or diabetogenic effects. Research has shown that AOD-9604 stimulates lipolysis and inhibits lipogenesis in adipose tissue through the activation of beta-adrenergic signaling pathways, effectively promoting fat oxidation while sparing lean muscle mass. Unlike intact growth hormone, AOD-9604 does not influence insulin-like growth factor 1 (IGF-1) levels or alter blood glucose, making it a compelling candidate for metabolic research focused on body composition. Preclinical and early clinical studies have demonstrated its potential to reduce visceral and subcutaneous fat deposits, particularly in abdominal regions, without the joint pain, edema, or insulin resistance associated with full-length hGH therapy.
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Dr. Elena Marchetti
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University of Edinburgh
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Independent Researcher
London
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Postdoctoral Scientist
Cambridge Institute